Aptose Biosciences 株価情報 (NASDAQ: APTO)

最新ニュース Aptose Biosciences (NASDAQ:APTO) 株価情報

Aptose Biosciences

Aptose Biosciences Inc is a clinical-stage biotechnology company committed to discovering and developing personalized therapies addressing unmet medical needs in oncology. The Company's small molecule cancer therapeutics pipeline includes products designed to provide single agent efficacy and to enhance the efficacy of other anti-cancer therapies and regimens without overlapping toxicities.

Aptose Biosciences Inc

Aptorum Group Limited - Class A Ordinary Shares

Aptorum Group Ltd

Aptos - United States Dollar

On Thursday, Aptose Biosciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) announced that the Cohort Safety Review Committee monitoring Phase 1/2 TUSCANY trial of tuspetinib in combination with standard of care dosing of venetoclax and azacitidine (TUS+VEN+AZA triplet) has approved escalating from 40 mg TUS to 80 mg TUS based on its favorable review of data from the first <a target="_blank" href="https://www.benzinga.com/pressreleases/25/02/g43844887/aptose-announces-positive-clinical-safety-review-committee-csrc-approval-to-dose-escalate-in-phase" rel="noreferrer noopener">four patients in the trial</a>.
The TUS+VEN+AZA triplet is being developed as a frontline therapy to treat large, mutationally diverse populations of newly diagnosed acute myeloid leukemia (AML) patients who are ineligible to receive induction chemotherapy.
No significant safety concerns or dose-limiting toxicities (DLTs) have been reported, including no prolonged myelosuppression of subjects in remission. All four subjects treated in the 40 mg cohort remain in the study, while enrollment is open for the 80 mg cohort.
Multiple U.S. sites are enrolling in the TUSCANY trial, with an anticipated enrollment of 18-24 patients by mid-late 2025. Data will be released as it becomes available.
Three patients with unmutated (wildtype) FLT3 (FLT3-WT) completed Cycle 1 of treatment with no dose-limiting toxicities (DLTs) and no TUS dose adjustments. Two FLT3-WT patients achieved complete remissions (CR and CRh) by the end of Cycle 1. A patient with biallelic TP53 mutations and a complex karyotype obtained CR.
The third FLT3-WT patient experienced significant reductions in bone marrow leukemic blasts during Cycle 1 and remains on therapy in Cycle 2.
The fourth patient, harboring FLT3-ITD and NPM1 mutations, is currently dosing in Cycle 1 and is not yet eligible for response evaluation.
Pharmacokinetic (PK) analyses for TUS show plasma levels unaffected by adding AZA.
Price Action: APTO stock is up 31.50% at $0.20 at last check Thursday.
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<li><a href="https://www.benzinga.com/trading-ideas/movers/25/02/43852969/whats-going-on-with-stmicroelectronics-stock-today" target="_blank" rel="noreferrer noopener">What&#8217;s Going On With STMicroelectronics Stock Today?</a></li>
</ul>
Photo by Aunt Spray via Shutterstock

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APTO

Why Is Penny Stock Aptose Biosciences Trading Higher On Thursday?

WIIM

Aptose shares are trading higher after a Cohort Safety Review Committee unanimously approved escalating the TUS dose from 40 mg to 80 mg in the Phase 1/2 TUSCANY trial.

Aptose Announces Cohort Safety Review Committee Monitoring Phase 1/2 TUSCANY Trial Of TUS+VEN+AZA Unanimously Approved Escalating From 40 mg TUS To 80 mg TUS

Aptose Biosciences shares are trading lower after the company announced a 1-for-30 reverse stock split.

Shares of Global Blue Group Holding AG (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GB#NYSE">GB</a>) rose sharply during Wednesday's pre-market trading session after the company announced it will be acquired by Shift4 for <a href="https://www.benzinga.com/quote/gb/analyst-ratings">$7.50 per share</a>.
Global Blue Group shares jumped 18.3% to $7.37 in the pre-market trading session.
Here are some other stocks moving in pre-market trading.
<h3 class="wp-block-heading">Gainers</h3>
<ul>
<li>Cycurion, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CYCU#NASDAQ">CYCU</a>) rose 132.5% to $7.79 in pre-market trading after dipping 72% on Tuesday.</li>
<li>OSR Holdings, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OSRH#NASDAQ">OSRH</a>) shares jumped 96.4% to $6.11 in pre-market trading after gaining 3% on Tuesday.</li>
<li>Lytus Technologies Holdings PTV. Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LYT#NASDAQ">LYT</a>) gained 52.7% to $0.34 in pre-market trading after dipping 14% on Tuesday.</li>
<li>ReShape Lifesciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RSLS#NASDAQ">RSLS</a>) gained 43.3% to $1.55 in pre-market trading. ReShape Lifesciences shares dipped around 54% on Tuesday after the company announced a $6 million public offering of 2,575,107 units at $2.33 per unit.</li>
<li>Sintx Technologies, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SINT#NASDAQ">SINT</a>) shares climbed 38.3% to $3.90 in pre-market trading. Sintx Technologies announced the issuance of U.S. patent no. 12,239,761 by the United States Patent and Trademark Office.</li>
<li>NewGenIvf Group Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NIVF#NASDAQ">NIVF</a>) gained 35.2% to $2.96 in pre-market trading after gaining around 12% on Tuesday.</li>
<li>TruGolf Holdings, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TRUG#NASDAQ">TRUG</a>) gained 33.1% to $0.5444 in pre-market trading after the company guided 2024 sales of $22.5 million and 2H adjusted EBITDA above $2.2 million.</li>
<li>Aditxt, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ADTX#NASDAQ">ADTX</a>) gained 22.3% to $0.1345 in pre-market after surging 57% on Tuesday.</li>
<li>Mercurity Fintech Holding Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MFH#NASDAQ">MFH</a>) rose 14.5% to $8.00. MFH&#8217;s majority-owned subsidiary Aifinity Base Limited plans to manufacture advanced liquid cooling solutions for Nvidia&#xAE; chip-powered AI data centers and high-performance computing.</li>
</ul>
<h3 class="wp-block-heading">Losers</h3>
<ul>
<li>Movano Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MOVE#NASDAQ">MOVE</a>) shares fell 36.4% to $3.25 in pre-market trading.</li>
<li>Aptose Biosciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) shares fell 25.5% to $0.1439 in pre-market trading after gaining around 8% on Tuesday.</li>
<li>Design Therapeutics, Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DSGN#NASDAQ">DSGN</a>) dipped 24.5% to $3.120 in pre-market trading.</li>
<li>Supernus Pharmaceuticals, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SUPN#NASDAQ">SUPN</a>) fell 22% to $31.00 in pre-market trading after the company announced that the Phase 2b study of SPN-820 in adults with treatment-resistant depression did not demonstrate a statistically significant improvement on the primary endpoint of change from baseline in the Montgomery-Åsberg Depression Rating Scale.</li>
<li>InnovAge Holding Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INNV#NASDAQ">INNV</a>) fell 21.1% to $2.70 in today's pre-market trading. InnovAge recently reported worse-than-expected second-quarter financial results.</li>
<li>MGO Global, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MGOL#NASDAQ">MGOL</a>) shares tumbled 20.9% to $0.3680 in pre-market trading after dipping 35% on Tuesday. MGO Global&#8217;s stockholders approved business combination with Heidmar.</li>
<li>Bumble Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BMBL#NASDAQ">BMBL</a>) declined 17.3% to $6.70 in pre-market trading after the company issued first-quarter revenue guidance below estimates and announced a quarter-over-quarter decline in paying app users.</li>
<li>Gentherm Incorporated (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/THRM#NASDAQ">THRM</a>) fell 17% to $30.00 in pre-market trading following weak quarterly results.</li>
<li>Celanese Corporation (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CE#NYSE">CE</a>) shares dipped 13.5% to $60.50 in pre-market trading after the company issued first-quarter EPS guidance below estimates.</li>
<li>Nexa Resources S.A. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NEXA#NYSE">NEXA</a>) fell 10.6% to $4.60 in pre-market trading following a 7% decline on Tuesday.</li>
</ul>
Now Read This: 
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<li><a href="https://www.benzinga.com/trading-ideas/long-ideas/25/02/43776863/top-3-risk-off-stocks-which-could-rescue-your-portfolio-this-quarter-3">Top 3 Risk Off Stocks Which Could Rescue Your Portfolio This Quarter</a></li>
</ul>

Pre-Market Outlook

Markets

ADTX

BMBL

CYCU

DSGN

INNV

MGOL

MOVE

NEXA

NIVF

OSRH

RSLS

SINT

SUPN

THRM

TRUG

Why Global Blue Group Shares Are Trading Higher By Around 18%; Here Are 20 Stocks Moving Premarket

U.S. stock futures fell on Wednesday after scaling fresh records in Tuesday&#8217;s session. The futures of all four benchmark indices were trading lower in the premarket.
President Donald Trump, on Tuesday, announced plans to impose a 25% tariff on auto imports, along with tariffs on pharmaceuticals and semiconductor chips.
The auto tariffs are expected to take effect by April 2, based on a report from his cabinet. Tariffs on pharmaceuticals and chips will also start at 25% or higher, with increases over the year. Trump did not specify a start date, allowing manufacturers time to establish U.S. factories to avoid the tariffs.
The 10-year Treasury yield stood at 4.56%, while the two-year yield was at 4.30%. According to the CME Group's FedWatch <a href="https://www.cmegroup.com/markets/interest-rates/cme-fedwatch-tool.html">tool</a>, there is a 97.5% chance that the Federal Reserve will keep interest rates unchanged for the March meeting. 
<figure class="wp-block-table is-style-stripes"> 
<table>
<tbody>
<tr>
<td>Futures</td>
<td>Change (+/-)</td>
</tr>
<tr>
<td>Nasdaq 100</td>
<td>-0.09%</td>
</tr>
<tr>
<td>S&amp;P 500</td>
<td>-0.10%</td>
</tr>
<tr>
<td>Dow Jones</td>
<td>-0.10%</td>
</tr>
<tr>
<td>Russell 2000</td>
<td>-0.43%</td>
</tr>
</tbody>
</table>
</figure>
The SPDR S&amp;P 500 ETF Trust (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SPY#NYSE">SPY</a>) and Invesco QQQ Trust ETF (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QQQ#NASDAQ">QQQ</a>), which track the S&amp;P 500 index and Nasdaq 100 index, respectively, were trading below the flatline on Wednesday. SPY fell 0.12% to $610.73, and QQQ dropped 0.093% to $538.87, according to <a href="https://pro.benzinga.com/dashboard">Benzinga Pro</a> data.
Cues From The Last Session
Energy, materials, and utilities sectors led the gains in U.S. stocks on Tuesday, propelling the S&amp;P 500 to a<a href="https://www.benzinga.com/news/earnings/25/02/43806227/sp-500-settles-at-record-high-ahead-of-fed-minutes-investor-sentiment-improves-fear-greed-index-moves-to-neutral-zone"> record-high close</a>. Despite the overall positive trend, communication services and consumer discretionary sectors declined on Tuesday. 
The broader market awaited the release of the latest FOMC minutes on Wednesday and monitored other ongoing geopolitical developments.
Last week saw positive momentum across equity markets. The S&amp;P 500 was approximately up 1.5%, the Dow Jones Industrial Average rose 0.6%, and the Nasdaq Composite gained 2.6% last week.
In company news, Fluor Corp. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/FLR#NYSE">FLR</a>) shares plummeted over 8% after the company reported quarterly earnings and revenue below expectations. On the economic front, the NY Empire State Manufacturing Index exceeded forecasts, rising 18.3 points to +5.7 in February.
<figure class="wp-block-table is-style-stripes"> 
<table>
<tbody>
<tr>
<td>Index</td>
<td>Performance (+/-)</td>
<td>Value</td>
</tr>
<tr>
<td>Nasdaq Composite</td>
<td>0.072%</td>
<td>20,041.26</td>
</tr>
<tr>
<td>S&amp;P 500</td>
<td>0.24%</td>
<td>6,129.58</td>
</tr>
<tr>
<td>Dow Jones</td>
<td>0.023%</td>
<td>44,556.34</td>
</tr>
<tr>
<td>Russell 2000</td>
<td>0.45%</td>
<td>2,290.35</td>
</tr>
</tbody>
</table>
</figure>
Insights From Analysts
Ryan Detrick, the chief market strategist at Carson Research, pointed out that the S&amp;P 500 scaled its second all-time high of 2025 on Tuesday.
This was the 1,243rd record high over the 17,176 trading days since 1957 when the gauge increased to having 500 stocks.
Processing this data, Detrick highlighted that the S&amp;P 500 hits a new all-time high about once every three weeks.
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">And with that we have the 2nd all-time high of 2025 for the S&amp;P 500. Since 1957 (when it become 500 stocks) this is 1,243 ATHs out of 17,176 trading days. In other words, a new ATH happens about once every 3 wks. New highs happen, congrats to the investors who remembered. <a href="https://t.co/D30va9bi5Y">pic.twitter.com/D30va9bi5Y</a>
&mdash; Ryan Detrick, CMT (@RyanDetrick) <a href="https://twitter.com/RyanDetrick/status/1891961462475591906?ref_src=twsrc%5Etfw">February 18, 2025</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></div>
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He also addressed a very important question, "Should you buy when stocks are all-time highs?" in one of his X posts.
Detrick said, "Don&#8217;t be scared of new highs". He substantiated his claims by adding that the index is usually up 71% of the times, a year after scaling an all-time high.
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<div class="wp-block-embed__wrapper">
<blockquote class="twitter-tweet" data-width="500" data-dnt="true">Should you buy when stocks are all-time highs? That&#39;s a popular question we often get. My take is don&#39;t be scared of new highs, as the S&amp;P 500 is up a year later 71% of the time after an ATH and up a median of 8.3%. In other words, about normal returns. <a href="https://t.co/I01bT0Bgwg">pic.twitter.com/I01bT0Bgwg</a>
&mdash; Ryan Detrick, CMT (@RyanDetrick) <a href="https://twitter.com/RyanDetrick/status/1891968184590246018?ref_src=twsrc%5Etfw">February 18, 2025</a></blockquote>
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</figure>
Talking about the fresh record, Nathan Peterson, director of derivatives analysis at the <a href="https://www.schwab.com/learn/story/stock-market-update-open">Schwab Center</a> for Financial Research said: &#8220;It seems that stocks can maintain a bullish bias provided the economic data and earnings growth estimates hold up and yields on the 10-year Treasury note remain below the mid-January high of 4.8%." 
According to economist Jeremy Siegel, despite the uncertainties, "The stock market continues to perform well, particularly in the tech sector, even as leadership has broadened beyond last year's AI-driven rally."
Professor of finance at the University of Pennsylvania, Siegel also added that "Tesla took a hit on competition from China's BYD, now the world's largest EV maker. Nvidia was hit after the DeepSeek news, but overall, the tech leaders have remained resilient."
See Also: <a href="https://www.benzinga.com/money/how-to-trade-futures">How to Trade Futures </a>
Upcoming Economic Data
Here&#8217;s what investors will keep On Wednesday:
<ul>
<li>On Wednesday, January&#8217;s housing starts and building permits data will be out by 8:30 a.m., ET.</li>
</ul>
<ul>
<li>January&#8217;s minutes of the Federal Reserve Open Market Committee meeting will be released at 2:00 p.m., ET.</li>
</ul>
<ul>
<li>Fed Vice Chairman Philip Jefferson will speak at 5:00 p.m., ET.</li>
</ul>
Stocks In Focus:
<ul>
<li>Analog Devices Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ADI#NASDAQ">ADI</a>) was up 0.58% in the premarket on Wednesday ahead of its earnings, which will be released before the opening bell. Analysts expect it to report quarterly earnings of $1.54 per share on revenue of $2.36 billion.</li>
</ul>
<ul>
<li>Etsy Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ETSY#NASDAQ">ETSY</a>) advanced 1.24% as Wall Street expects it to report quarterly earnings of 93 cents per share on revenue of $862.82 million. before the opening bell.</li>
</ul>
<ul>
<li>Carvana Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CVNA#NYSE">CVNA</a>) rose 0.99% ahead of its earnings, which will be released after the closing bell. Analysts expect it to report quarterly earnings of 29 cents per share on revenue of $3.31 billion.</li>
</ul>
<ul>
<li>Koninklijke Philips NV (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/PHG#NYSE">PHG</a>) tumbled 11.69% after reporting downbeat results for its fourth quarter.</li>
</ul>
<ul>
<li>Wix.Com Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/WIX#NASDAQ">WIX</a>) jumped 6.68% after reporting earnings of $1.93 per share for the fourth quarter, which beat the analyst consensus. But its sales of $460.455 million missed the consensus of $461.748 million.</li>
</ul>
<ul>
<li>Aptose Biosciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) plunged 28.20% after it announced a 1-for-30 reverse share split approved by its board of directors. The consolidation will reduce outstanding common shares from 64,301,183 to approximately 2,143,372 shares.</li>
</ul>
<ul>
<li>Crown Crafts Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CRWS#NASDAQ">CRWS</a>) slumped 34.12%, continuing to fall after its third-quarter sales, profit and EPS declined.</li>
</ul>
Commodities, Gold And Global Equity Markets:
Crude oil futures were trading higher in the early New York session by 0.89% to hover around $72.47 per barrel.
The gold spot index was up by 0.30% to $2,944.20 per ounce. The Dollar Index was up 0.10% at 107.157 level.
Asian markets ended mostly lower on Wednesday. China's CSI 300, and South Korea's Kospi index rose. Whereas, Australia's ASX 200, India's S&amp;P BSE Sensex, Hong Kong's Hang Seng, and Japan's Nikkei 225 index fell. European markets were mixed in trade.
Read Next:
<ul>
<li><a href="https://www.benzinga.com/25/02/43806703/mark-zuckerbergs-meta-platforms-dips-below-short-term-average-as-it-snaps-20-day-winning-run">Meta Stock Dips Below Short-Term Average As Mark Zuckerberg-Led Tech Giant Snaps 20-Day Winning Streak</a></li>
</ul>
Photo courtesy: Shutterstock

Analyst Color

Earnings

Economics

Analyst Ratings

CRWS

CVNA

ETSY

US Stocks Likely To Open Lower Following Fresh Records From Previous Session: Expert Says, 'Don't Be Scared Of New Highs'

Stock Split

Aptose Biosciences Plans To Consolidate Common Shares On The Basis Of 1- For-30 Reverse Share Split

U.S. stock futures rose on Tuesday after a long weekend following a mixed close on Friday. Monday was a federal holiday owing to the Presidents Day celebrations. The futures of all four benchmark indices advanced.
Investors will be on the lookout for global macroeconomic factors as the U.S. and Russian officials met in Riyadh on Tuesday for their highest-level talks yet on the Ukraine war.
Discussions focused on ending the three-year conflict and improving relations, potentially paving the way for a summit between Presidents Donald Trump and Vladimir Putin.
Walmart Inc.&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/WMT#NYSE">WMT</a>) earnings will be a key focus this week, along with reports from U.S.-listed Chinese e-commerce giants Alibaba Group Holding ADR (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BABA#NYSE">BABA</a>) and Baidu Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BIDU#NASDAQ">BIDU</a>). Online used-car retailer Carvana Co. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CVNA#NYSE">CVNA</a>), and EV maker Rivian Automotive Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RIVN#NASDAQ">RIVN</a>) will also report this week.
The 10-year Treasury yield stood at 4.50%, while the two-year yield was at 4.27%. According to the CME Group's FedWatch <a href="https://www.cmegroup.com/markets/interest-rates/cme-fedwatch-tool.html">tool</a>, there is a 97.5% chance that the Federal Reserve will keep interest rates unchanged for the March meeting.
<figure class="wp-block-table is-style-stripes"> 
<table>
<tbody>
<tr>
<td>Futures</td>
<td>Change (+/-)</td>
</tr>
<tr>
<td>Nasdaq 100</td>
<td>0.37%</td>
</tr>
<tr>
<td>S&amp;P 500</td>
<td>0.29%</td>
</tr>
<tr>
<td>Dow Jones</td>
<td>0.10%</td>
</tr>
<tr>
<td>Russell 2000</td>
<td>0.15%</td>
</tr>
</tbody>
</table>
</figure>
The SPDR S&amp;P 500 ETF Trust (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/SPY#NYSE">SPY</a>) and Invesco QQQ Trust ETF (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QQQ#NASDAQ">QQQ</a>), which track the S&amp;P 500 index and Nasdaq 100 index, respectively, rose in premarket on Tuesday. SPY rose 0.30% to $611.52, and QQQ advanced 0.42% to $540.42, according to <a href="https://pro.benzinga.com/dashboard">Benzinga Pro</a> data.
Cues From The Last Session
Tech and Communication Services bucked the negative trend, closing higher on Friday, while Healthcare, Consumer Staples, and Utilities led losses as most S&amp;P 500 sectors declined. 
Despite Friday&#8217;s mixed results, for the last week, the S&amp;P 500 gained 1.5%, the Dow 0.6%, and the Nasdaq 2.6% led by weaker-than-expected retail sales which were down 0.9% in January.
<figure class="wp-block-table is-style-stripes"> 
<table>
<tbody>
<tr>
<td>Index</td>
<td>Performance (+/-)</td>
<td>Value</td>
</tr>
<tr>
<td>Nasdaq Composite</td>
<td>0.41%</td>
<td>20,026.77 </td>
</tr>
<tr>
<td>S&amp;P 500</td>
<td>-0.0072%</td>
<td>6,114.63</td>
</tr>
<tr>
<td>Dow Jones</td>
<td>-0.37%</td>
<td>44,546.08</td>
</tr>
<tr>
<td>Russell 2000</td>
<td>-0.097%</td>
<td>2,279.98</td>
</tr>
</tbody>
</table>
</figure>
Insights From Analysts
Ryan Detrick, the chief market strategist at Carson Research pointed out that seven out of the total broad 11 sectors have outperformed the S&amp;P 500 index on a year-to-date basis.
&#8220;We&#8217;ve been pounding the table for broadening out and we think this will continue,&#8221; he added.
<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"> 
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">After a big week for tech last week, all 11 sectors are up on the year and seven groups are outperforming the S&amp;P 500. We&#39;ve been pounding the table for broadening out and we think this will continue. <a href="https://t.co/F2sPwCw8wj">pic.twitter.com/F2sPwCw8wj</a>
&mdash; Ryan Detrick, CMT (@RyanDetrick) <a href="https://twitter.com/RyanDetrick/status/1891675975995244713?ref_src=twsrc%5Etfw">February 18, 2025</a></blockquote>
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</figure>
The S&amp;P 500 has surged 60% in the past two years, a significant increase. However, according to Bravos Research historically, similar rapid gains have often been followed by substantial market downturns.
The downturns have occurred three out of the last four times after such a surge was witnessed. Bravos highlights that one instance did lead to a rapid and dramatic market rise, calling it a &#8220;melt-up.&#8221;
The question, now is whether the current situation will follow the more common pattern of decline or the rarer &#8220;melt-up&#8221; scenario.
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<blockquote class="twitter-tweet" data-width="500" data-dnt="true">S&amp;P 500 has seen a 60% gain in just 2 years The last 3 out of 4 times saw big market declines after But 1 time it did end up in a true melt-up Which one is it going to be this time around? <a href="https://t.co/QywZJANK2U">pic.twitter.com/QywZJANK2U</a>
&mdash; Bravos Research (@bravosresearch) <a href="https://twitter.com/bravosresearch/status/1891174402554802495?ref_src=twsrc%5Etfw">February 16, 2025</a></blockquote>
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Talking about the economic impact Ed Yardeni in his Market Call blog said, &#8220;So far, Trump&#8217;s tariff turmoil seems to be weighing more on the U.S., Canada, Mexico, and many other emerging markets than on China and most European countries.&#8221;
That could change once reciprocal tariffs are imposed by the U.S. in early April, unless Trump changes his mind, again, added Yardeni.
See Also: <a href="https://www.benzinga.com/money/how-to-trade-futures">How to Trade Futures </a>
Upcoming Economic Data
Here&#8217;s what investors will keep an eye on this week:
<ul>
<li>On Tuesday, February&#8217;s Empire State manufacturing survey data will be released at 8:30 a.m., ET.</li>
</ul>
<ul>
<li>February&#8217;s home builder confidence index will be announced at 10:00 a.m., ET.</li>
</ul>
<ul>
<li>San Francisco Fed President Mary C Daly will speak at 10:20 a.m., while Fed Vice Chairman for Supervision Michael Barr will speak at 1:00 p.m., ET.</li>
</ul>
<ul>
<li>On Wednesday, January&#8217;s housing starts and building permits data will be out by 8:30 a.m., ET.</li>
</ul>
<ul>
<li>January&#8217;s minutes of the Federal Reserve Open Market Committee meeting will be released at 2:00 p.m., ET.</li>
</ul>
<ul>
<li>Fed Vice Chairman Philip Jefferson will speak at 5:00 p.m., ET.</li>
</ul>
<ul>
<li>On Thursday, initial jobless claims till Feb. 15 will be announced and the Philadelphia Fed manufacturing survey for Feb will be out by 8:30 a.m., ET.</li>
</ul>
<ul>
<li>Chicago Fed President Austan Goolsbee will be speaking at 09:35 a.m., ET.</li>
</ul>
<ul>
<li>January&#8217;s leading economic indicators will be released at 10:00 a.m., ET.</li>
</ul>
<ul>
<li>Vice Chairman for Supervision Michael Barr will speak again at 2:30 p.m., ET.</li>
</ul>
<ul>
<li>Fed Governor Adriana Kugler will be speaking at 5:00 p.m., ET.</li>
</ul>
<ul>
<li>On Friday, February&#8217;s S&amp;P flash U.S. services PMI and manufacturing PMI will be out by 9:45 a.m., ET.</li>
</ul>
<ul>
<li>The final consumer sentiment data for February and existing home sales data for January will be out by 10:00 a.m., ET.</li>
</ul>
<ul>
<li>Fed Vice Chairman Philip Jefferson will speak again and San Francisco Fed President Mary C Daly will also speak at 11:30 a.m., ET.</li>
</ul>
Stocks In Focus:
<ul>
<li>Medtronic PLC. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/MDT#NYSE">MDT</a>) was up 0.75% in the premarket on Tuesday ahead of its earnings, which will be released before the opening bell. Analysts expect it to report quarterly earnings of $1.36 per share on revenue of $8.32 billion.</li>
</ul>
<ul>
<li>Fluor Corp. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/FLR#NYSE">FLR</a>) advanced 1.34% as Wall Street expects it to report quarterly earnings of 77 cents per share on revenue of $4.42 billion before the opening bell.</li>
</ul>
<ul>
<li>Baidu Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BIDU#NASDAQ">BIDU</a>) dropped 2.28% ahead of its earnings, which will be released before the opening bell. Analysts expect it to report quarterly earnings of $1.78 per share on revenue of $4.56 billion.</li>
</ul>
<ul>
<li>Occidental Petroleum Corp. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/OXY#NYSE">OXY</a>) jumped 1.64% as Wall Street expects it to report quarterly earnings of 70 cents per share on revenue of $7.05 billion after the closing bell.</li>
</ul>
<ul>
<li>Aptose Biosciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) climbed 17.78% after securing two funding agreements; a $25 million committed equity facility allowing them to sell shares to an investor over two years, and a $1 million at-the-market facility for Nasdaq share sales.</li>
</ul>
<ul>
<li>Pagaya Technologies Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PGY#NASDAQ">PGY</a>) zoomed 23.68% after posting record total revenue and other income of $279 million in the fourth quarter along with a record network volume of $2.6 billion.</li>
</ul>
<ul>
<li>MGO Global Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MGOL#NASDAQ">MGOL</a>) plunged 26.42% as shareholders approved the proposed business combination with Heidmar at a special meeting on Friday.</li>
</ul>
Commodities, Gold And Global Equity Markets:
Crude oil futures were trading higher in the early New York session by 1.56% to hover around $71.81 per barrel.
The gold spot index was up by 0.48% to $2,912.19 per ounce. The Dollar Index was up 0.34% at 106.932 level.
Asian markets were mixed on Tuesday. Australia's ASX 200, China's CSI 300, and India's S&amp;P BSE Sensex index fell. Whereas, South Korea's Kospi, Hong Kong's Hang Seng, and Japan's Nikkei 225 index advanced. European markets were mixed in trade as well.
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Photo courtesy: Shutterstock

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US Stocks Likely To Open Higher Amid Ukraine Peace Talk Hopes As Russian, American Officials Meet

Shares of GCL Global Holdings Ltd (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GCL#NASDAQ">GCL</a>) rose sharply in today&#8217;s pre-<a href="https://www.benzinga.com/quote/GCL">market trading</a>.
GCL and RF Acquisition Corp. disclosed the successful completion of their business combination.
GCL Global shares jumped 107.1% to $6.13 in the pre-market trading session.
Here are some other stocks moving in pre-market trading.
<h3 class="wp-block-heading">Gainers</h3>
<ul>
<li>Energy Focus, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EFOI#NASDAQ">EFOI</a>) rose 70% to $2.21 in pre-market trading after gaining over 5% on Friday.</li>
<li>GlycoMimetics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/GLYC#NASDAQ">GLYC</a>) shares jumped 53.1% to $0.4442 in pre-market trading. GlycoMimetics and Crescent amended merger agreement.</li>
<li>Aditxt, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ADTX#NASDAQ">ADTX</a>) gained 30.1% to $0.0915 in pre-market trading after reporting financial and operational results for third quarter of fiscal year 2025.</li>
<li>Pagaya Technologies Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PGY#NASDAQ">PGY</a>) gained 23.3% to $18.95 in pre-market trading. Pagaya Technologies, last week, reported better-than-expected quarterly financial results.</li>
<li>TNL Mediagene (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TNMG#NASDAQ">TNMG</a>) gained 21.4% to $2.99 in pre-market trading after declining around 4% on Friday.</li>
<li>H&amp;E Equipment Services, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HEES#NASDAQ">HEES</a>) gained 21.2% to $106.00 in pre-market trading.</li>
<li>Cloudastructure Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CSAI#NASDAQ">CSAI</a>) shares climbed 18.7% to $22.61 in pre-market trading after dipping 49% on Friday.</li>
<li>Aptose Biosciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) gained 17.8% to $0.2120 in pre-market. Aptose, last week, entered into $25 million committed equity facility and enters at-the-market distributions.</li>
<li>Grab Holdings Limited (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/GRAB#NYSE">GRAB</a>) rose 14.3% to $5.60 in pre-market trading. Soros Fund Management dissolved share stake in Grab Holdings.</li>
</ul>
<h3 class="wp-block-heading">Losers</h3>
<ul>
<li>ReShape Lifesciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RSLS#NASDAQ">RSLS</a>) shares fell 60.4% to $0.9199 in pre-market trading after the company reported the pricing of upsized $6.0 million public offering.</li>
<li>Design Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/DSGN#NASDAQ">DSGN</a>) shares fell 50.7% to $2.01 in pre-market trading.</li>
<li>Northern Technologies International Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NTIC#NASDAQ">NTIC</a>) dipped 37.5% to $7.00 in pre-market trading.</li>
<li>Matrix Service Company (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MTRX#NASDAQ">MTRX</a>) fell 30.2% to $10.61 in pre-market trading.</li>
<li>European Wax Center, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EWCZ#NASDAQ">EWCZ</a>) fell 27.7% to $5.31 in today's pre-market trading.</li>
<li>INLIF Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/INLF#NASDAQ">INLF</a>) fell 26.4% to $12.02 in pre-market trading after jumping 81% on Friday.</li>
<li>MGO Global, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MGOL#NASDAQ">MGOL</a>) shares tumbled 25.2% to $0.5370 in pre-market trading. MGO Global&#8217;s stockholders approved business combination with Heidmar.</li>
<li>National Energy Services Reunited Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NESR#NASDAQ">NESR</a>) declined 23.7% to $7.20 in pre-market trading.</li>
<li>LiveWire Group, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LVWR#NASDAQ">LVWR</a>) fell 22.5% to $2.02 in pre-market trading.</li>
<li>Emerald Holding, Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/EEX#NYSE">EEX</a>) shares dipped 10.7% to $3.9100 in pre-market trading.</li>
</ul>
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Why GCL Global Holdings Shares Are Trading Higher By Around 107%; Here Are 20 Stocks Moving Premarket

Offerings

Aptose Enters $25M Committed Equity Facility And Enters At-the-Market Distributions

CORRECTION:HC Wainwright &amp; Co. analyst Joseph Pantginis reiterates Aptose Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) with a Buy and maintains $2 price target.(Firm Name Change From RBC To HC Wainwright &amp; Co.)

Price Target

Reiteration

CORRECTION: HC Wainwright & Co. Reiterates Buy on Aptose Biosciences, Maintains $2 Price Target (Firm Name Change From RBC To HC Wainwright & Co.)

RBC Capital analyst Joseph Pantginis reiterates Aptose Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) with a Buy and maintains $2 price target.

RBC Capital Reiterates Buy on Aptose Biosciences, Maintains $2 Price Target

Aptose Biosciences shares are trading higher after the company reported early safety and response results for its Phase 1/2 TUSCANY trial of Tuspetinib.

Aptose Biosciences Reported Promising Early Safety And Response Results From Newly Diagnosed AML Patients In The Phase 1/2 TUSCANY Trial

Aptose Reports Early Safety And Response Results In Phase 1/2 TUSCANY Trial Of Tuspetinib In Combination With Standard Of Care Dosing Of Venetoclax And Azacitidine; Says TUS+VEN+AZA Triplet Achieved Cycle 1 Complete Remission In TP53-Mutated/CK AML

HC Wainwright &amp; Co. analyst Joseph Pantginis reiterates Aptose Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) with a Buy and maintains $2 price target.

HC Wainwright & Co. Reiterates Buy on Aptose Biosciences, Maintains $2 Price Target

Aptose Announces First AML Patients Dosed With Tuspetinib Triplet Frontline Therapy In Tuscany Trial

Shares of Rumble Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RUM#NASDAQ">RUM</a>) rose sharply in today's pre-market trading after the company announced it has entered into a definitive agreement for a strategic <a href="https://www.benzinga.com/24/12/42634166/rumble-stock-soars-on-775-million-investment-from-tether-what-to-know">investment of $775 million from Tether</a>.
Tether (CRYPTO: <a class="ticker" href="https://www.benzinga.com/quote/">USDT</a>) has agreed to purchase 103.33 million shares of Rumble Class A Common Stock at a price per share of $7.50, totaling $775 million in gross proceeds to Rumble.
Rumble shares jumped 43.3% to $10.31 in the pre-market trading session.
Here are some other stocks moving in pre-market trading.
<h3 class="wp-block-heading">Gainers</h3>
<ul>
<li>Reliance Global Group, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/RELI#NASDAQ">RELI</a>) gained 234% to $4.01 in pre-market trading.</li>
<li>Phio Pharmaceuticals Corp. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PHIO#NASDAQ">PHIO</a>) gained 88.6% to $3.32 in pre-market trading. Phio Pharmaceuticals, last week, announced a $1.15 million registered direct offering priced at-the-market under Nasdaq rules.</li>
<li>Edible Garden AG Incorporated (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EDBL#NASDAQ">EDBL</a>) climbed 82.3% to $0.4334 in pre-market trading after surging 63% on Friday. Edible Garden recently announced it experienced a 51% year-over-year increase in its preliminary Thanksgiving period sales.</li>
<li>JIADE Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/JDZG#NASDAQ">JDZG</a>) gained 60.9% to $0.8530 in pre-market trading. JIADE received Nasdaq notification letter regarding minimum bid price deficiency.</li>
<li>American Battery Technology Company (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ABAT#NASDAQ">ABAT</a>) rose 44.1% to $1.60 in pre-market trading. On Friday, American Battery Technology priced its $5 million registered direct offering of 5 million shares at $1.00 per share.</li>
<li>SEALSQ Corp (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/LAES#NASDAQ">LAES</a>) gained 30.9% to $3.60 in pre-market trading after jumping more than 36% on Friday.</li>
<li>Brenmiller Energy Ltd (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/BNRG#NASDAQ">BNRG</a>) rose 28.8% to $0.9700 in pre-market trading after the company was awarded ISO/IEC 27001:2022 certification.</li>
<li>Honda Motor Co., Ltd. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/HMC#NYSE">HMC</a>) gained 18% to $28.19 in pre-market trading. Honda Motor and Nissan Motor Co. Ltd. (OTC:<a class="ticker" href="https://www.benzinga.com/stock/NSANY#OTC">NSANY</a>) have started talks for a potential merger.</li>
<li>Kodiak Sciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/KOD#NASDAQ">KOD</a>) rose 14.9% to $9.94 in pre-market trading.</li>
</ul>
<h3 class="wp-block-heading">Losers</h3>
<ul>
<li>Conduit Pharmaceuticals Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CDT#NASDAQ">CDT</a>) shares tumbled 28.9% to $0.0531 in pre-market trading after jumping 14% on Friday. Conduit Pharmaceuticals recently announced it entered an agreement with Sarborg to leverage AI and its cybernetics platform to evaluate key deliverables across multiple areas of operations.</li>
<li>Helius Medical Technologies, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HSDT#NASDAQ">HSDT</a>) declined 25.7% to $0.6759 in pre-market trading after jumping around 101% on Friday.</li>
<li>Onfolio Holdings, Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ONFO#NASDAQ">ONFO</a>) fell 24.4% to $1.21 in pre-market trading. Onfolio Holdings announced a quarterly preferred stock cash dividend of 75 cents per share.</li>
<li>iLearningEngines, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AILE#NASDAQ">AILE</a>) shares fell 24.3% to $0.6703 in pre-market trading after declining 9% on Friday.</li>
<li>ConnectM Technology Solutions Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CNTM#NASDAQ">CNTM</a>) shares dipped 20% to $0.83 in pre-market trading after falling 8% on Friday. ConnectM Technology Solutions, last week, announced a year-over-year increase in third-quarter revenue results.</li>
<li>TPI Composites, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TPIC#NASDAQ">TPIC</a>) fell 19.2% to $1.94 in today's pre-market trading after jumping 97% on Friday.</li>
<li>Aptose Biosciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) dipped 17.8% to $0.2293 in pre-market trading after jumping 64% on Friday. Aptose Biosciences, last week, announced it was granted an extension to provide compliance evidence for a continued Nasdaq listing.</li>
<li>Core Laboratories Inc. (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CLB#NYSE">CLB</a>) fell 11% to $15.00 in pre-market trading.</li>
<li>Astria Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ATXS#NASDAQ">ATXS</a>) shares fell 10.8% to $8.53 in pre-market trading.</li>
<li>SIGA Technologies, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SIGA#NASDAQ">SIGA</a>) fell 8.5% to $5.41 in pre-market trading.</li>
</ul>
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Why Rumble Shares Are Trading Higher By Around 43%; Here Are 20 Stocks Moving Premarket

Shares of FedEx Corporation (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/FDX#NYSE">FDX</a>) rose sharply in today's pre-market trading as the company posted stronger-than-expected <a href="https://www.benzinga.com/news/earnings/24/12/42605034/fedex-stock-rallies-on-better-than-expected-q2-eps-freight-spin-off-announcement">results for its second quarter</a>.
The company also announced that it has decided to pursue a full separation of FedEx Freight through the capital markets, creating a new publicly traded company.
FedEx shares jumped 8.7% to $299.80 in the pre-market trading session.
Here are some other stocks moving in pre-market trading.
<h3 class="wp-block-heading">Gainers</h3>
<ul>
<li>Aptose Biosciences Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/APTO#NASDAQ">APTO</a>) gained 80.5% to $0.3070 in pre-market trading after the company announced it was granted an extension to provide compliance evidence for a continued Nasdaq listing.</li>
<li>Psyence Biomedical Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PBM#NASDAQ">PBM</a>) gained 67.4% to $4.12 in pre-market trading fater jumping more than 60% on Thursday. The company announced it has entered into an IP licensing and mutual exclusivity agreement with Optimi Health Corp.</li>
<li>Ocean Biomedical, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/OCEA#NASDAQ">OCEA</a>) climbed 62.5% to $0.9576 in pre-market trading.</li>
<li>Nvni Group Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVNI#NASDAQ">NVNI</a>) gained 52.8% to $4.08 in pre-market trading after jumping 317% on Thursday.</li>
<li>Humacyte, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/HUMA#NASDAQ">HUMA</a>) rose 44.5% to $5.00 in pre-market trading as the company announced the FDA approval of SYMVESS&#x2122; (acellular tissue engineered vessel-tyod) for the treatment of extremity vascular trauma.</li>
<li>Aadi Bioscience, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/AADI#NASDAQ">AADI</a>) gained 35.3% to $3.14 in pre-market trading after the company secured $100 million PIPE financing and announced the sale of FYARRO for $100 million.</li>
<li>Xilio Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/XLO#NASDAQ">XLO</a>) gained 26.9% to $1.19 in pre-market trading after the company announced 7.85 million of its shares was acquired by Gilead Sciences.</li>
<li>ZJK Industrial Co., Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ZJK#NASDAQ">ZJK</a>) rose 17.4% to $8.78 in pre-market trading after dipping over 12% on Thursday.</li>
<li>Clearwater Paper Corporation (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/CLW#NYSE">CLW</a>) gained 11.8% to $27.62 in pre-market trading.</li>
</ul>
<h3 class="wp-block-heading">Losers</h3>
<ul>
<li>Molecular Templates, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MTEM#NASDAQ">MTEM</a>) shares tumbled 49.5% to $0.1785 in pre-market trading after the company announced notice of delisting and failure to satisfy continued listing rules.</li>
<li>PainReform Ltd. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/PRFX#NASDAQ">PRFX</a>) declined 36.4% to $7.10 in pre-market trading after jumping around 410% on Thursday.</li>
<li>Cara Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CARA#NASDAQ">CARA</a>) shares fell 26.7% to $0.2998 in pre-market trading after jumping 56% on Thursday. Cara Therapeutics recently announced it entered into an all-stock merger with Tvardi Therapeutics.</li>
<li>Novo Nordisk A/S (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/NVO#NYSE">NVO</a>) fell 25.8% to $76.80 in pre-market trading. Novo Nordisk said CagriSema demonstrated weight loss in adults with obesity or overweight in the REDEFINE 1 trial.</li>
<li>XChange TEC.INC (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/XHG#NASDAQ">XHG</a>) shares dipped 25.2% to $0.9730 in pre-market trading after climbing 65% on Thursday.</li>
<li>Mobix Labs, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MOBX#NASDAQ">MOBX</a>) fell 24.5% to $1.57 in today's pre-market trading after reporting third-quarter results.</li>
<li>Zoomcar Holdings, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/ZCAR#NASDAQ">ZCAR</a>) dipped 23.6% to $1.94 in pre-market trading. Zoomcar said it launched Zoomcar Cabs, which are affordable car rentals with drivers as a new offering.</li>
<li>Mesoblast Limited (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/MESO#NASDAQ">MESO</a>) shares fell 18.1% to $13.72 in pre-market trading. Mesoblast shares jumped over 36% on Thursday after the company announced the FDA approved Ryoncilas the first mesenchymal stromal cell therapy in the United States.</li>
<li>Candel Therapeutics, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CADL#NASDAQ">CADL</a>) fell 13.1% to $8.66 in pre-market trading after jumping over 52% on Thursday.</li>
<li>Quantum Computing Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/QUBT#NASDAQ">QUBT</a>) fell 11.1% to $13.46 in pre-market trading after declining 41% on Thursday.</li>
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Now Read This: 
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<li><a href="https://www.benzinga.com/news/earnings/24/12/42609619/sp-500-nasdaq-end-in-red-as-investor-sentiment-declines-micron-tumbles-after-sales-miss-greed-index-in-extreme-fear-zone">S&amp;P 500, Nasdaq End In Red As Investor Sentiment Declines, Micron Tumbles After Sales Miss: Greed Index In &#8216;Extreme Fear&#8217; Zone</a></li>
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Why FedEx Shares Are Trading Higher By Around 9%; Here Are 20 Stocks Moving Premarket

Aptose Biosciences shares are trading higher after the company announced it was granted an extension to provide compliance evidence for a continued Nasdaq listing.

Press Releases

Aptose Biosciences Inc. Announces Closing of $8 Million Public Offering

Aptose Signs CRADA with NCI to Develop Tuspetinib for AML and MDS in Newly Launched MyeloMATCH Precision Medicine Trials

Aptose Clinical Data Featured in Poster Presentation at the 2024 ASH Annual Meeting Support Tuspetinib Triple Drug Therapy for Newly Diagnosed AML

Aptose Announces Publication of Preclinical Data in AACR Journal Demonstrating Tuspetinib's Unique Mechanism of Action and Synthetic Lethality on AML Cells When Combined with Venetoclax

Aptose Announces Positive Decision by Nasdaq Hearings Panel

Aptose Announces First AML Patients Dosed with Tuspetinib Triplet Frontline Therapy in TUSCANY Trial

Aptose's Frontline Triple Drug Therapy with Tuspetinib Achieves Notable Responses in Newly Diagnosed AML Patients in the Phase 1/2 TUSCANY Trial

Aptose Enters into $25 Million Committed Equity Facility and Establishes New At-The-Market Facility

Aptose Announces Reverse Share Split

Aptose Announces Positive Clinical Safety Review Committee (CSRC) Approval to Dose Escalate in Phase 1/2 Tuscany Trial of Frontline Triple Drug Therapy with Tuspetinib Amid Complete Responses and Favorable Safety in First Cohort

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