| May 31, 2024 | Michael Anthony White | CHIEF SCIENTIFIC OFFICER | 0.00 | $24.55 | -$666.37K | SELL-OPTIONS | 0.00% | 0.00 | May 29 | View |
| May 16, 2024 | Yujiro Hata | PRESIDENT AND CEO | 0.00 | $23.29 | -$6.64M | SELL-OPTIONS | 0.00% | 677.89K | May 14 - May 16 | View |
| Feb 13, 2024 | Andres Ruiz Briseno | SEE REMARKS | -2.00K | $46.02 | -$92.04K | SELL | -7.54% | 24.53K | Feb 09 | View |
| Feb 12, 2024 | Yujiro Hata | PRESIDENT AND CEO | 0.00 | $24.77 | -$4.07M | SELL-OPTIONS | 0.00% | 677.89K | Feb 08 - Feb 09 | View |
| Feb 05, 2024 | Yujiro Hata | PRESIDENT AND CEO | 0.00 | $24.66 | -$25.55K | SELL-OPTIONS | 0.00% | 677.89K | Feb 01 | View |
| Jan 24, 2024 | Andres Ruiz Briseno | SEE REMARKS | -2.00K | $42.03 | -$84.05K | SELL | -7.01% | 26.53K | Jan 22 | View |
| Jan 17, 2024 | Andres Ruiz Briseno | SEE REMARKS | -2.00K | $38.01 | -$76.03K | SELL | -6.55% | 28.53K | Jan 12 | View |
| Jan 17, 2024 | Yujiro Hata | PRESIDENT AND CEO | 0.00 | $22.23 | -$2.69M | SELL-OPTIONS | 0.00% | 677.89K | Jan 12 - Jan 16 | View |
| Dec 19, 2023 | Jason Throne | CHIEF LEGAL OFFICER | 10.00K | $22.61 | -$146.87K | SELL-OPTIONS | ∞ | 10.00K | Dec 15 - Dec 18 | View |
| Dec 19, 2023 | Yujiro Hata | PRESIDENT AND CEO | 0.00 | $19.67 | -$2.30M | SELL-OPTIONS | 0.00% | 677.89K | Dec 15 | View |
| Dec 18, 2023 | Andres Ruiz Briseno | SEE REMARKS | -2.00K | $34.00 | -$68.00K | SELL | -6.15% | 30.53K | Dec 14 | View |
| Nov 07, 2023 | Jason Throne | CHIEF LEGAL OFFICER | 0.00 | $21.48 | -$88.96K | SELL-OPTIONS | 0.00% | 0.00 | Nov 03 | View |
| Sep 14, 2023 | Jason Throne | CHIEF LEGAL OFFICER | 0.00 | $21.43 | -$17.14K | SELL-OPTIONS | 0.00% | 0.00 | Sep 12 | View |
| Sep 06, 2023 | Jason Throne | CHIEF LEGAL OFFICER | 0.00 | $21.44 | -$65.88K | SELL-OPTIONS | 0.00% | 0.00 | Sep 01 - Sep 05 | View |
| Sep 06, 2023 | Andres Ruiz Briseno | SEE REMARKS | -2.00K | $30.01 | -$60.02K | SELL | -5.79% | 32.53K | Sep 01 | View |
| Aug 31, 2023 | Paul A Stone | CHIEF FINANCIAL OFFICER | -5.00K | $28.87 | -$144.35K | SELL | -34.96% | 9.30K | Aug 29 | View |
| Aug 23, 2023 | Paul A Stone | CHIEF FINANCIAL OFFICER | -978.00 | $26.40 | -$25.82K | SELL | -6.40% | 14.30K | Aug 21 | View |
| Aug 18, 2023 | Paul A Stone | CHIEF FINANCIAL OFFICER | -4.02K | $26.38 | -$106.11K | SELL | -20.84% | 15.28K | Aug 16 - Aug 18 | View |
| Aug 11, 2023 | Jason Throne | CHIEF LEGAL OFFICER | 0.00 | $19.21 | -$58.73K | SELL-OPTIONS | 0.00% | 0.00 | Aug 09 | View |
| Aug 11, 2023 | Paul A Stone | CHIEF FINANCIAL OFFICER | -2.50K | $25.05 | -$62.61K | SELL | -11.47% | 19.30K | Aug 09 | View |
| Jul 12, 2023 | Jason Throne | CHIEF LEGAL OFFICER | 0.00 | $16.55 | -$122.44K | SELL-OPTIONS | 0.00% | 0.00 | Jul 10 | View |
| Jun 02, 2023 | Jason Throne | CHIEF LEGAL OFFICER | 0.00 | $15.01 | -$63.79K | SELL-OPTIONS | 0.00% | 0.00 | May 31 - Jun 01 | View |
| May 24, 2023 | Jason Throne | CHIEF LEGAL OFFICER | 0.00 | $15.00 | -$8.00K | SELL-OPTIONS | 0.00% | 0.00 | May 22 | View |
| Oct 07, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | 0.00 | $18.72 | -$22.93K | SELL-OPTIONS | 0.00% | 78.79K | Oct 04 | View |
| Sep 09, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | 0.00 | $17.13 | -$236.51K | SELL-OPTIONS | 0.00% | 78.79K | Sep 07 - Sep 08 | View |
| Sep 09, 2021 | Paul A Stone | SVP, CHIEF FINANCIAL OFFICER | -2.50K | $27.42 | -$68.54K | SELL | -16.19% | 12.94K | Sep 07 | View |
| Sep 07, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | -10.00K | $25.09 | -$250.94K | SELL | -11.26% | 78.79K | Sep 02 | View |
| Aug 11, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | -10.00K | $13.64 | -$257.80K | SELL | -10.12% | 88.79K | Aug 09 | View |
| Jul 29, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | 0.00 | $15.38 | -$195.31K | SELL-OPTIONS | 0.00% | 98.79K | Jul 27 | View |
| Jul 29, 2021 | Jason Throne | SVP, GENERAL COUNSEL | 0.00 | $19.25 | -$118.28K | SELL-OPTIONS | 0.00% | 0.00 | Jul 27 | View |
| Jul 08, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | 0.00 | $14.58 | -$22.98K | SELL-OPTIONS | 0.00% | 98.79K | Jul 06 | View |
| Jul 08, 2021 | Jason Throne | SVP, GENERAL COUNSEL | 0.00 | $15.38 | -$137.18K | SELL-OPTIONS | 0.00% | 0.00 | Jul 06 | View |
| Jun 17, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | 0.00 | $14.70 | -$77.81K | SELL-OPTIONS | 0.00% | 98.79K | Jun 16 - Jun 17 | View |
| Jun 09, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | 0.00 | $13.57 | -$19.95K | SELL-OPTIONS | 0.00% | 98.79K | Jun 07 | View |
| May 13, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | 0.00 | $13.57 | -$66.49K | SELL-OPTIONS | 0.00% | 98.79K | May 11 | View |
| Feb 10, 2021 | Michael P Dillon | SVP, CHIEF SCIENTIFIC OFFICER | 0.00 | $13.83 | -$69.10K | SELL-OPTIONS | 0.00% | 98.79K | Feb 09 | View |
| Feb 10, 2021 | Mark Lackner | SVP, HEAD BIOLOGY | 0.00 | $14.00 | -$28.09K | SELL-OPTIONS | 0.00% | 0.00 | Feb 08 - Feb 10 | View |
| Feb 04, 2021 | PIL PARTNERS BVFFUND VALUE BIOTECHNOLOGYBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS LtdBVF GP HOLDINGS LLCINCIL BVFMARK LAMPERT | — | -46.41K | $18.00 | -$835.36K | SELL | -16.60% | 233.15K | Feb 02 | View |
| Jan 28, 2021 | Mark Lackner | SVP, HEAD BIOLOGY | -1.00K | $12.42 | -$36.58K | SELL | -100.00% | 0.00 | Jan 26 | View |
| Dec 08, 2020 | Jason Throne | — | -1.98K | $15.37 | -$30.41K | SELL | -100.00% | 0.00 | Dec 04 | View |
| Nov 13, 2020 | AM Ventures IV LPAM CoInvestors IV LPAM Partners IV LLCAM Opportunities I LPAM Opportunities I GP LLCJOHN DIEKMANAndrew SchwabSCOTT ROCKLAGE | — | -800.00K | $13.66 | -$10.93M | SELL | -67.54% | 384.50K | Nov 11 | View |
| Jul 02, 2020 | PIL PARTNERS BVFFUND VALUE BIOTECHNOLOGYBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS LtdBVF GP HOLDINGS LLCINCIL BVFMARK LAMPERT | — | 2.53K | $13.32 | $33.70K | PURCHASE | 1.08% | 237.47K | Jun 30 | View |
| Jun 22, 2020 | PIL PARTNERS BVFFUND VALUE BIOTECHNOLOGYBVF I GP LLCBIOTECHNOLOGY VALUE FUND II LPBVF II GP LLCBiotechnology Value Trading Fund OS LPBVF Partners OS LtdBVF GP HOLDINGS LLCINCIL BVFMARK LAMPERT | — | 118.00K | $14.31 | $1.69M | PURCHASE | 98.83% | 237.39K | Jun 19 - Jun 22 | View |
| Jun 19, 2020 | Paul A Stone | — | 0.00 | $11.30 | -$41.39K | OPTION EXERCISE | 0.00% | 15.00K | Jun 17 | View |
| Jun 18, 2020 | Mark Lackner | — | 0.00 | $10.38 | -$68.52K | OPTION EXERCISE | 0.00% | 0.00 | Jun 16 - Jun 17 | View |
| Jun 08, 2020 | Jason Throne | — | -2.21K | $8.66 | -$19.09K | SELL | -100.00% | 0.00 | Jun 04 | View |
| Jun 04, 2020 | Mark Lackner | — | -845.00 | $9.21 | -$7.78K | SELL | -100.00% | 0.00 | Jun 02 | View |
| May 30, 2019 | Alexandria Venture Investments LLC | 10% OWNER | 432.38K | $10.00 | $500.00K | BUY | ∞ | 432.38K | May 28 | View |
| May 28, 2019 | John D Diekman | DIRECTOR | 2.65M | $10.00 | $2.50M | BUY | ∞ | 118.52K | May 28 | View |
| May 28, 2019 | Paul A Stone | SVP, GENERAL COUNSEL | 2.65M | $10.00 | $2.50M | BUY | ∞ | 118.52K | May 28 | View |
| May 28, 2019 | AM Ventures IV LPAM CoInvestors IV LPAM Partners IV LLCSCOTT ROCKLAGEAndrew Schwab | 10% OWNER | 3.15M | $10.00 | $7.50M | BUY | ∞ | 500.00K | May 28 | View |
| May 28, 2019 | Timothy M Shannon | DIRECTOR | 2.66M | $10.00 | $4.00M | BUY | ∞ | 2.66M | May 28 | View |
| May 28, 2019 | CANAAN X LPCanaan Partners X LLC | 10% OWNER | 2.66M | $10.00 | $4.00M | BUY | ∞ | 2.66M | May 28 | View |
