Neurocrine Biosciences 株価情報 (NASDAQ: NBIX)

最新ニュース Neurocrine Biosciences (NASDAQ:NBIX) 株価情報

Neurocrine Biosciences

Neurocrine Biosciences Inc is a research-based pharmaceutical company advancing drug candidates in the central nervous system and endocrine-related categories. The company's three late stage clinical programs are elagolix which is hormone releasing antagonist for women's health, opicapone which is an inhibitor for parkinson's patients, and ingrezza for tourette syndrome.

Neurocrine Biosciences, Inc. - Common Stock

Neurocrine Biosciences Inc

UBS analyst Ashwani Verma maintains Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) with a Buy and raises the price target from $162 to $176.

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NBIX

UBS Maintains Buy on Neurocrine Biosciences, Raises Price Target to $176

On Monday, Neurocrine Biosciences, Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) <a target="_blank" href="https://www.benzinga.com/pressreleases/25/01/n43251057/neurocrine-biosciences-announces-amendment-to-strategic-collaboration-with-takeda-to-develop-and-c" rel="noreferrer noopener">amended its agreement</a> with Takeda Pharmaceutical Co Ltd (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/TAK#NYSE">TAK</a>) to develop and commercialize osavampator (NBI-1065845/TAK-653).
Under the amended agreement, Neurocrine will obtain exclusive rights for all indications to develop and commercialize osavampator for patients with inadequate response to treatment of major depressive disorder (MDD) in all territories worldwide except&nbsp;Japan, where Takeda will reacquire exclusive rights.
Also Read: <a target="_blank" href="https://www.benzinga.com/24/12/42508449/neurocrines-drug-gains-fda-nod-as-first-targeted-cah-treatment-analyst-highlights-blockbuster-potential" rel="noreferrer noopener">Neurocrine&#8217;s Drug Gains FDA Nod As First Targeted Treatment For Certain Type Of Inherited Disorder, Analyst Highlights Blockbuster Potential</a>
Under the terms of the updated agreement, each company is responsible for development costs in their respective region, and both companies are eligible to receive royalty payments.
&#8220;With the recent successful completion of our End-of-Phase 2 meeting with FDA for osavampator, we look forward to beginning the Phase 3 program in the first half of this year,&#8221; said Kyle Gano, Chief Executive Officer at Neurocrine Biosciences.
In 2020,&nbsp;Neurocrine Biosciences&nbsp;and Takeda entered into a strategic collaboration to develop and commercialize compounds in depression and schizophrenia, including an exclusive license to both osavampator and NBI-1070770, which are being studied for the treatment of major depressive disorder, as well as a preclinical GPR139 antagonist development program.
Concurrently, Neurocrine Biosciences initiated a Phase 3 registrational study to evaluate the efficacy, safety and tolerability of osavampator as an adjunctive treatment to antidepressants for <a target="_blank" href="https://www.benzinga.com/pressreleases/25/01/n43266015/neurocrine-biosciences-announces-initiation-of-phase-3-registrational-program-for-osavampator-as-a" rel="noreferrer noopener">major depressive disorder</a>.
In&nbsp;April 2024, Neurocrine announced topline data for its Phase 2 SAVITRI study in <a target="_blank" href="https://www.benzinga.com/general/biotech/24/04/38386407/neurocrine-biosciences-says-treatment-can-alleviate-several-symptoms-associated-with-depressive-d" rel="noreferrer noopener">adult subjects with MDD</a>.
The study met its primary and&nbsp;key&nbsp;secondary endpoints, demonstrating that once-daily, oral administration of NBI-1065845 produced a statistically significant change from baseline in Montgomery Åsberg Depression Rating Scale (MADRS) total score at both Day 28 (primary) and Day 56 (secondary).&nbsp;
Price Action: NBIX stock is up 1.38% at $150.23 at the last check on Tuesday.
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Neurocrine Obtains Exclusive Rights For Depression Drug, Takeda Reacquires Japan Rights

Neurocrine Biosciences Initiates Phase 3 Registrational Program For Osavampator As Adjunctive Therapy For Treatment Of Major Depressive Disorder In Adults

Under the amended agreement, Neurocrine will obtain exclusive rights for all indications to develop and commercialize osavampator, a potential first-in-class AMPA positive allosteric modulator in development for patients with inadequate response to treatment of major depressive disorder (MDD) in all territories worldwide except Japan, where Takeda will reacquire exclusive rights. 
Under the terms of the updated agreement, each company is responsible for development costs in their respective region, and both companies are eligible to receive royalty payments.

Neurocrine Biosciences Amends Agreement With Takeda To Develop, Commercialize Osavampator; Takeda Reacquires Rights To Osavampator In Japan

<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4342843-1&amp;h=3800559142&amp;u=http%3A%2F%2Fwww.neurocrine.com%2F&amp;a=Neurocrine+Biosciences%2C+Inc.">Neurocrine Biosciences, Inc.</a> (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) today announced publication of a classic congenital adrenal hyperplasia (CAH)-focused supplement in The Journal of Clinical Endocrinology &amp; Metabolism (JCEM), sponsored by the company. The supplement, titled "<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=4342843-1&amp;h=1522570349&amp;u=https%3A%2F%2Facademic.oup.com%2Fjcem%2Fissue%2F110%2FSupplement_1&amp;a=Challenges+and+Opportunities+in+the+Management+of+Classic+Congenital+Adrenal+Hyperplasia+Due+to+21-Hydroxylase+Deficiency+Throughout+the+Lifetime">Challenges and Opportunities in the Management of Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Throughout the Lifetime</a>," contains eight review articles that provide a comprehensive look at the clinical, psychosocial, treatment-related and day-to-day challenges faced by individuals with classic CAH. JCEM is a leader in disseminating research that supports healthcare providers, patients and caregivers in advancing the understanding and management of various endocrinology conditions, such as CAH.

Neurocrine Announced Publication Of Supplement On Classic Congenital Adrenal Hyperplasia In The Journal Of Clinical Endocrinology & Metabolism, Covering Clinical, Psychosocial, Treatment Challenge

UBS analyst Ashwani Verma maintains Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) with a Buy and raises the price target from $142 to $162.

UBS Maintains Buy on Neurocrine Biosciences, Raises Price Target to $162

<ul>
<li>Narrative Review Assesses Current Treatment Challenges and the Evolving Classic Congenital Adrenal Hyperplasia (CAH) Therapeutic Landscape
<ul>
<li>Non-Glucocorticoid (GC) Mechanisms for Treatment of CAH Could Enable Control of Excess ACTH and Androgens Without the Need for High-Dose GCs, Reducing Related Complications Over a Lifetime</li>
</ul>
</li>
</ul>

Neurocrine Biosciences Publishes Narrative Review Discussing Challenges Of Traditional Glucocorticoid Treatment in Classic Congenital Adrenal Hyperplasia

Piper Sandler analyst David Amsellem reiterates Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) with a Overweight and maintains $160 price target.

Reiteration

Piper Sandler Reiterates Overweight on Neurocrine Biosciences, Maintains $160 Price Target

Barclays analyst Carter Gould maintains Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) with a Overweight and raises the price target from $160 to $165.

Barclays Maintains Overweight on Neurocrine Biosciences, Raises Price Target to $165

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<li>Neurocrine Biosciences, Inc. (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) stock rose 6.88%. The FDA approved Crenessity (crinecerfont) capsules and oral solution as an adjunctive treatment to glucocorticoid replacement to control androgens in adult and pediatric patients four years of age and older with <a href="https://www.benzinga.com//node/42508449" target="_blank" rel="noreferrer noopener">classic congenital adrenal hyperplasia (CAH).</a></li>
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Photo by Sundry Photography via Shutterstock

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Teva Pharmaceutical, Li Auto, And Darden Restaurants Are Among Top Large Cap Gainers Last Week (December 16-20): Are The Others In Your Portfolio?

7 analysts have expressed a variety of opinions on Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) over the past quarter, offering a diverse set of opinions from bullish to bearish.
The following table summarizes their recent ratings, shedding light on the changing sentiments within the past 30 days and comparing them to the preceding months.
<table>
<thead>
<tr>
<th></th>
<th align="right">Bullish</th>
<th align="right">Somewhat Bullish</th>
<th align="right">Indifferent</th>
<th align="right">Somewhat Bearish</th>
<th align="right">Bearish</th>
</tr>
</thead>
<tbody>
<tr>
<td>Total Ratings</td>
<td align="right">2</td>
<td align="right">2</td>
<td align="right">3</td>
<td align="right">0</td>
<td align="right">0</td>
</tr>
<tr>
<td>Last 30D</td>
<td align="right">0</td>
<td align="right">0</td>
<td align="right">0</td>
<td align="right">0</td>
<td align="right">0</td>
</tr>
<tr>
<td>1M Ago</td>
<td align="right">1</td>
<td align="right">1</td>
<td align="right">0</td>
<td align="right">0</td>
<td align="right">0</td>
</tr>
<tr>
<td>2M Ago</td>
<td align="right">1</td>
<td align="right">0</td>
<td align="right">0</td>
<td align="right">0</td>
<td align="right">0</td>
</tr>
<tr>
<td>3M Ago</td>
<td align="right">0</td>
<td align="right">1</td>
<td align="right">3</td>
<td align="right">0</td>
<td align="right">0</td>
</tr>
</tbody>
</table>
The 12-month price targets assessed by analysts reveal further insights, featuring an average target of $151.86, a high estimate of $190.00, and a low estimate of $114.00. A negative shift in sentiment is evident as analysts have decreased the average price target by 1.5%. 
<img src="https://www.benzinga.com/files/images/story/2024/1734721222_0.png" alt="price target chart" />
<h2>Diving into Analyst Ratings: An In-Depth Exploration</h2>
An in-depth analysis of recent analyst actions unveils how financial experts perceive Neurocrine Biosciences. The following summary outlines key analysts, their recent evaluations, and adjustments to ratings and price targets.
<table>
<thead>
<tr>
<th>Analyst</th>
<th>Analyst Firm</th>
<th>Action Taken</th>
<th>Rating</th>
<th>Current Price Target</th>
<th>Prior Price Target</th>
</tr>
</thead>
<tbody>
<tr>
<td>Laura Chico</td>
<td>Wedbush</td>
<td>Maintains</td>
<td>Outperform</td>
<td>$148.00</td>
<td>$148.00</td>
</tr>
<tr>
<td>Andrew Fein</td>
<td>HC Wainwright &amp; Co.</td>
<td>Maintains</td>
<td>Buy</td>
<td>$190.00</td>
<td>$190.00</td>
</tr>
<tr>
<td>Andrew Fein</td>
<td>HC Wainwright &amp; Co.</td>
<td>Maintains</td>
<td>Buy</td>
<td>$190.00</td>
<td>$190.00</td>
</tr>
<tr>
<td>Evan Seigerman</td>
<td>BMO Capital</td>
<td>Lowers</td>
<td>Market Perform</td>
<td>$114.00</td>
<td>$128.00</td>
</tr>
<tr>
<td>Danielle Brill</td>
<td>Raymond James</td>
<td>Announces</td>
<td>Outperform</td>
<td>$155.00</td>
<td>-</td>
</tr>
<tr>
<td>Brian Abrahams</td>
<td>RBC Capital</td>
<td>Maintains</td>
<td>Sector Perform</td>
<td>$133.00</td>
<td>$133.00</td>
</tr>
<tr>
<td>Brian Abrahams</td>
<td>RBC Capital</td>
<td>Lowers</td>
<td>Sector Perform</td>
<td>$133.00</td>
<td>$136.00</td>
</tr>
</tbody>
</table>
<h3>Key Insights:</h3>
<ul>
<li>Action Taken: Analysts respond to changes in market conditions and company performance, frequently updating their recommendations. Whether they 'Maintain', 'Raise' or 'Lower' their stance, it reflects their reaction to recent developments related to Neurocrine Biosciences. This information offers a snapshot of how analysts perceive the current state of the company.</li>
<li>Rating: Analyzing trends, analysts offer qualitative evaluations, ranging from 'Outperform' to 'Underperform'. These ratings convey expectations for the relative performance of Neurocrine Biosciences compared to the broader market.</li>
<li>Price Targets: Analysts explore the dynamics of price targets, providing estimates for the future value of Neurocrine Biosciences's stock. This examination reveals shifts in analysts' expectations over time.</li>
</ul>
Assessing these analyst evaluations alongside crucial financial indicators can provide a comprehensive overview of Neurocrine Biosciences's market position. Stay informed and make well-judged decisions with the assistance of our Ratings Table.
<a href="https://www.benzinga.com/quote/NBIX/analyst-ratings?utm_source=Benzinga Insights">Stay up to date on Neurocrine Biosciences analyst ratings.</a>
<h2>Discovering Neurocrine Biosciences: A Closer Look</h2>
Neurocrine Biosciences Inc is a research-based pharmaceutical company advancing drug candidates in the central nervous system and endocrine-related categories. The company's three late stage clinical programs are elagolix which is hormone releasing antagonist for women's health, opicapone which is an inhibitor for parkinson's patients, and ingrezza for tourette syndrome.
<h3>Financial Milestones: Neurocrine Biosciences's Journey</h3>
Market Capitalization Analysis: Reflecting a smaller scale, the company's market capitalization is positioned below industry averages. This could be attributed to factors such as growth expectations or operational capacity.
Revenue Growth: Neurocrine Biosciences displayed positive results in 3 months. As of 30 September, 2024, the company achieved a solid revenue growth rate of approximately 24.72%. This indicates a notable increase in the company's top-line earnings. As compared to its peers, the company achieved a growth rate higher than the average among peers in Health Care sector.
Net Margin: Neurocrine Biosciences's net margin surpasses industry standards, highlighting the company's exceptional financial performance. With an impressive 20.86% net margin, the company effectively manages costs and achieves strong profitability.
Return on Equity (ROE): The company's ROE is a standout performer, exceeding industry averages. With an impressive ROE of 4.97%, the company showcases effective utilization of equity capital.
Return on Assets (ROA): Neurocrine Biosciences's financial strength is reflected in its exceptional ROA, which exceeds industry averages. With a remarkable ROA of 3.8%, the company showcases efficient use of assets and strong financial health.
Debt Management: The company maintains a balanced debt approach with a debt-to-equity ratio below industry norms, standing at 0.09.
<h2>The Basics of Analyst Ratings</h2>
Experts in banking and financial systems, analysts specialize in reporting for specific stocks or defined sectors. Their comprehensive research involves attending company conference calls and meetings, analyzing financial statements, and engaging with insiders to generate what are known as analyst ratings for stocks. Typically, analysts assess and rate each stock once per quarter.
Analysts may supplement their ratings with predictions for metrics like growth estimates, earnings, and revenue, offering investors a more comprehensive outlook. However, investors should be mindful that analysts, like any human, can have subjective perspectives influencing their forecasts.
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This article was generated by Benzinga's automated content engine and reviewed by an editor.

What Analysts Are Saying About Neurocrine Biosciences Stock

Needham analyst Ami Fadia reiterates Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) from Hold to Hold.

Needham Reiterates Hold on Neurocrine Biosciencesto Hold

WIIM

Neurocrine Biosciences shares are trading higher. Wedbush reiterated its Outperform rating on the stock and maintained its $148 price target.

On Friday, the FDA approved Neurocrine Biosciences, Inc.(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) Crenessity (crinecerfont)&nbsp;capsules and oral solution as&nbsp;an adjunctive treatment to glucocorticoid replacement to control androgens in adult and pediatric patients four years of age and older with classic <a target="_blank" href="https://www.benzinga.com/pressreleases/24/12/n42494466/neurocrine-biosciences-announces-fda-approval-of-crenessity-crinecerfont-a-first-in-class-treatmen" rel="noreferrer noopener">congenital adrenal hyperplasia (CAH).</a>
CAH is&nbsp;a rare, inherited disorder that affects the adrenal glands and causes them to be larger than normal.&nbsp;The adrenal glands are located above the kidneys and produce hormones that regulate blood sugar, blood pressure, and other bodily functions.
Also Read: <a target="_blank" href="https://www.benzinga.com/analyst-ratings/analyst-color/24/09/40857425/neurocrine-shifts-focus-to-new-schizophrenia-treatment-after-luvadaxistat-trial-mis" rel="noreferrer noopener">Neurocrine Shifts Focus To New Schizophrenia Treatment After Luvadaxistat Trial Misses Endpoint</a>
Crenessity, a potent and selective oral corticotropin-releasing factor type 1 receptor antagonist, is the first and only classic CAH treatment that directly reduces excess adrenocorticotropic hormone and downstream adrenal androgen production, allowing for glucocorticoid dose reduction.
Crenessity is expected to be commercially available in approximately one week. To centralize and simplify prescription fulfillment, the medication will be provided through PANTHERx Rare, a specialty pharmacy.
William Blair sees significant potential in the CAH market but acknowledges that for this to be a blockbuster $1 billion-plus commercial opportunity, there will need to be both patient and clinician education that supraphysiological (amounts greater than normally found in the body) glucocorticoid dosing would no longer be the only way to control androgen levels and prevent adrenal crises.
The analyst writes that focusing on educational initiatives and collaborating with patient advocacy groups, such as the CARES Foundation, is a smart move as Neurocrine prepares for its product launch.
While early-stage competitors like Crinetics Pharmaceuticals, Inc (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/CRNX#NASDAQ">CRNX</a>) show promising data, Neurocrine&#8217;s position as the first to market in treating congenital adrenal hyperplasia gives it a strong advantage.
Although investors have mixed opinions about the potential success of crinecerfont, William Blair sees opportunities for it to become a blockbuster drug alongside Ingrezza in the long run.
The analyst maintains the <a target="_blank" href="https://www.benzinga.com/quote/NBIX/analyst-ratings" rel="noreferrer noopener">Outperform rating on Neurocrine.</a>
Price Action: NBIX stock is up 2.80% at $130.25 premarket at last check Monday.
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Neurocrine's Drug Gains FDA Nod As First Targeted Treatment For Certain Type Of Inherited Disorder, Analyst Highlights Blockbuster Potential

Wedbush analyst Laura Chico reiterates Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) with a Outperform and maintains $148 price target.

Wedbush Reiterates Outperform on Neurocrine Biosciences, Maintains $148 Price Target

HC Wainwright &amp; Co. analyst Andrew Fein reiterates Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) with a Buy and maintains $190 price target.

HC Wainwright & Co. Reiterates Buy on Neurocrine Biosciences, Maintains $190 Price Target

<ul>
<li>CRENESSITY, the first new treatment available in 70 years to the classic congenital adrenal hyperplasia (CAH) community, offers a paradigm-shifting treatment approach
<ul>
<li>FDA approval supported by data from the largest-ever clinical trial program in pediatric and adult patients with classic CAHCRENESSITY is expected to be commercially available in approximately one week Rare Pediatric Disease Priority Review Voucher granted in connection with approval</li>
</ul>
</li>
</ul>

Reported Friday, Neurocrine Biosciences' CRENESSITY Receives FDA Approval, Revolutionizing Treatment For Classic Congenital Adrenal Hyperplasia

<figure class="wp-block-image aligncenter size-large"><img loading="lazy" decoding="async" width="1024" height="583" src="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092632/Black-Friday-Bargains-1024x583.jpg" alt="" class="wp-image-3701" srcset="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092632/Black-Friday-Bargains-1024x583.jpg 1024w,https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092632/Black-Friday-Bargains-300x171.jpg 300w,https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092632/Black-Friday-Bargains-768x437.jpg 768w,https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092632/Black-Friday-Bargains.jpg 1200w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure>
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<h2 class="wp-block-heading">Setting Up The Screen&nbsp;</h2>
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<li>Trades in U.S.</li>
<li>Has options.&nbsp;</li>
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<li><a href="https://www.investopedia.com/terms/p/piotroski-score.asp" target="_blank" rel="noreferrer noopener">Piotroski F-Score</a> >=8</li>
</ul>
The technical and valuation ratings are self-explanatory; the set-up rating measures the short-term consolidation of share prices. Each of those ratings is on a scale of 0 to 10, with 10 being best; the Piotroski F-Score is on a scale from 0 to 9, with 9 being best.&nbsp;
<h2 class="wp-block-heading">The Results&nbsp;</h2>
That screen yielded these four names:&nbsp;
<ul>
<li>Neurocrine Biosciences, Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>)</li>
<li>United Therapeutics Corp.&nbsp;(NYSE:<a class="ticker" href="https://www.benzinga.com/stock/UNH#NYSE">UNH</a>)</li>
<li>Supernous Pharmaceuticals, Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/SUPN#NASDAQ">SUPN</a>)</li>
<li>Expedia Group, Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/EXPE#NASDAQ">EXPE</a>)</li>
</ul>
<h2 class="wp-block-heading">Are These Stocks Worth Buying Now?&nbsp;</h2>
Maybe, but they&#8217;re probably not the best stocks to buy now. The best stocks typically aren&#8217;t cheap. In <a href="https://www.zerohedge.com/news/2024-11-20/post-just-saved-us-money-nvidia" target="_blank" rel="noreferrer noopener nofollow">a recent post</a> (&#8220;The Post That Just Saved Us Money On Nvidia&#8221;), I mentioned that I&#8217;d consider placing a bullish options trade on Nvidia Corporation (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NVDA#NASDAQ">NVDA</a>) again when it had a valuation rating of 6. I didn&#8217;t say a valuation rating of 7, because as long as the AI story continues, I don&#8217;t expect Nvidia to trade that cheaply. It may not even trade at a valuation rating of 6 in the near future, outside of a major market correction. Maybe it&#8217;s not worth waiting for one. 
<h2 class="wp-block-heading">The Valuation Ratings Of Portfolio Armor&#8217;s Top Ten Names</h2>
On Wednesday, I posted Portfolio Armor&#8217;s top ten names. Those are the ones are system estimates will have the highest returns over the next six months, net of hedging costs.
<figure class="wp-block-image aligncenter size-full"><a href="https://portfolioarmor.substack.com/p/top-names-11272024"><img loading="lazy" decoding="async" width="917" height="813" src="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092723/Top-Names-Wednesday.jpg" alt="" class="wp-image-3702" srcset="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092723/Top-Names-Wednesday.jpg 917w,https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092723/Top-Names-Wednesday-300x266.jpg 300w,https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092723/Top-Names-Wednesday-768x681.jpg 768w" sizes="(max-width: 917px) 100vw, 917px" /></a></figure>
Occasionally, we see some inexpensive stocks on that list (valuation ratings of 7 or so), but this week. The average valuation rating of the stocks in Wednesday&#8217;s top ten was 2.7. The overall top name,&nbsp;Tesla, Inc.&nbsp;(NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/TSLA#NASDAQ">TSLA</a>), had a valuation rating of 4.&nbsp;
<h2 class="wp-block-heading">The Limits Of Valuation </h2>
If you think about Tesla&#8217;s Optimus robots, you get a sense of the limitations of valuation in selecting stocks.
<figure class="wp-block-embed aligncenter is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio"> 
<div class="wp-block-embed__wrapper">
<iframe loading="lazy" title="Tesla Optimus Robot Explained" width="500" height="281" src="https://www.youtube.com/embed/1t1KMXSBrBM?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe>
</div>
</figure>
The robots aren&#8217;t for sale to the general public yet, so they don&#8217;t appear in any of the metrics that comprise Tesla&#8217;s valuation rating. But Tesla CEO Elon Musk says they&#8217;ll be the most popular product in the world. If he&#8217;s right, Tesla shares will be worth a lot more in the future.&nbsp;
Deciding whether Elon is likely to be right about those robots may turn out to be a more profitable exercise for investors than crunching valuation numbers. Our system defers to the wisdom of crowds on that&#8211;the crowd of stock investors, and the crowd of options traders. Its gauges of share price movement and options sentiment suggest it makes sense to bet on Tesla now.&nbsp;
Would you like a heads up when we place our next trade based on our top names? If so, you can subscribe to our trading Substack/occasional email list below.&nbsp;
Are you are concerned about market risk? You can download our optimal hedging app by clicking on the QR code below, or aiming your iPhone camera at it.
<figure class="wp-block-image size-full"><a href="https://apps.apple.com/us/app/portfolio-armor/id394951144"><img loading="lazy" decoding="async" width="200" height="197" src="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29092919/QR-Code-8.jpg" alt="" class="wp-image-3703" /></a></figure>
If you&#8217;d like to stay in touch
You can scan for optimal hedges for individual securities, find our current top ten names,&nbsp;on&nbsp;<a href="https://portfolioarmor.com/">our website</a>.&nbsp;You can also follow Portfolio Armor on X&nbsp;<a href="https://twitter.com/portfolioarmor">here</a>, or become a free subscriber to our trading Substack using the link below (we&#8217;re using that for our occasional emails now).
<figure class="wp-block-image aligncenter size-full"><a href="https://portfolioarmor.substack.com/"><img loading="lazy" decoding="async" width="602" height="418" src="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29093038/Widget-8.jpg" alt="" class="wp-image-3704" srcset="https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29093038/Widget-8.jpg 602w,https://contributor-assets.benzinga.com/wp-content/uploads/2024/11/29093038/Widget-8-300x208.jpg 300w" sizes="(max-width: 602px) 100vw, 602px" /></a></figure>

EXPE

NVDA

SUPN

TSLA

Screening For Black Friday Bargains In The Stock Market

A substantial insider activity was disclosed on November 12, as ROBERTS, Chief Medical Officer at Neurocrine Biosciences (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>), reported the exercise of a large sell of company stock options.
What Happened: A notable Form 4 filing on Tuesday with the <a href="https://www.sec.gov/Archives/edgar/data/0000914475/000091447524000220//Archives/edgar/data/914475/000091447524000220/0000914475-24-000220-index.htm">U.S. Securities and Exchange Commission</a> revealed that ROBERTS, Chief Medical Officer at Neurocrine Biosciences, exercised stock options for 7,345 shares of NBIX, resulting in a transaction value of $334,925.
Neurocrine Biosciences shares are trading, exhibiting up of 0.2% and priced at $127.27 during Wednesday's morning. This values ROBERTS's 7,345 shares at $334,925.
<h3>Discovering Neurocrine Biosciences: A Closer Look</h3>
Neurocrine Biosciences Inc is a research-based pharmaceutical company advancing drug candidates in the central nervous system and endocrine-related categories. The company's three late stage clinical programs are elagolix which is hormone releasing antagonist for women's health, opicapone which is an inhibitor for parkinson's patients, and ingrezza for tourette syndrome.
<h3>Neurocrine Biosciences's Economic Impact: An Analysis</h3>
Revenue Growth: Neurocrine Biosciences displayed positive results in 3 months. As of 30 September, 2024, the company achieved a solid revenue growth rate of approximately 24.72%. This indicates a notable increase in the company's top-line earnings. As compared to competitors, the company encountered difficulties, with a growth rate lower than the average among peers in the Health Care sector.
Key Profitability Indicators:
<ul>
<li>
Gross Margin: Achieving a high gross margin of 98.71%, the company performs well in terms of cost management and profitability within its sector.
</li>
<li>
Earnings per Share (EPS): With an EPS below industry norms, Neurocrine Biosciences exhibits below-average bottom-line performance with a current EPS of 1.28.
</li>
</ul>
Debt Management: Neurocrine Biosciences's debt-to-equity ratio is below the industry average. With a ratio of 0.09, the company relies less on debt financing, maintaining a healthier balance between debt and equity, which can be viewed positively by investors.
Insights into Valuation Metrics:
<ul>
<li>
Price to Earnings (P/E) Ratio: The P/E ratio of 33.88 is lower than the industry average, implying a discounted valuation for Neurocrine Biosciences's stock.
</li>
<li>
Price to Sales (P/S) Ratio: The current P/S ratio of 5.87 is below industry norms, suggesting potential undervaluation and presenting an investment opportunity for those considering sales performance.
</li>
<li>
EV/EBITDA Analysis (Enterprise Value to its Earnings Before Interest, Taxes, Depreciation &amp; Amortization): Neurocrine Biosciences's EV/EBITDA ratio, surpassing industry averages at 21.38, positions it with an above-average valuation in the market.
</li>
</ul>
Market Capitalization: Indicating a reduced size compared to industry averages, the company's market capitalization poses unique challenges.
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<h3>Unmasking the Significance of Insider Transactions</h3>
It's important to note that insider transactions alone should not dictate investment decisions, but they can provide valuable insights.
Within the legal framework, an "insider" is defined as any officer, director, or beneficial owner holding more than ten percent of a company's equity securities as per Section 12 of the Securities Exchange Act of 1934. This includes executives in the c-suite and major hedge funds. These insiders are mandated to disclose their transactions through a Form 4 filing, to be submitted within two business days of the transaction.
The initiation of a new purchase by a company insider serves as a strong indication that they expect the stock to rise.
However, insider sells may not always signal a bearish view and can be influenced by various factors.
<h3>Transaction Codes Worth Your Attention</h3>
Delving into transactions, <a href="https://www.benzinga.com/money/investing-tools">investors</a> typically prioritize those unfolding in the open market, as precisely outlined in Table I of the Form 4 filing. A P in Box 3 indicates a purchase, while S signifies a sale. Transaction code C signals the conversion of an option, and transaction code A denotes a grant, award, or other acquisition of securities from the company.
<a href="https://www.benzinga.com/sec/insider-trades/search/index?company_cik=0000914475">Check Out The Full List Of Neurocrine Biosciences's Insider Trades.</a>
Insider Buying Alert: Profit from C-Suite Moves
Benzinga Edge reveals every insider trade in real-time. Don't miss the next big stock move driven by insider confidence. Unlock this ultimate sentiment indicator now. <a href="https://www.benzinga.com/premium/ideas/benzinga-edge-checkout/?t=Be8be9arja3be22in8&amp;utm_source=benzinga-insights">Click here for access</a>.
This article was generated by Benzinga's automated content engine and reviewed by an editor.

Insider Trades

Strategic Sale: EIRY ROBERTS Decides To Exercise Options Worth $334K At Neurocrine Biosciences

On Monday,&nbsp;AbbVie&nbsp;Inc (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/ABBV#NYSE">ABBV</a>) stock plunged after two trials investigating emraclidine as a once-daily, oral monotherapy treatment for adults with schizophrenia failed&nbsp;<a target="_blank" href="https://www.benzinga.com/general/biotech/24/11/41884798/abbvies-emraclidine-for-schizophrenia-surprisingly-disappoints-analyst-says-pipeline-is-underappreciated" rel="noreferrer noopener">two Phase 2 trials</a>.
The studies did not meet their primary endpoint of showing a statistically significant improvement in the change from baseline in the Positive and Negative Syndrome Scale (PANSS) total score compared to the placebo group at week 6.
Truist says due to the failure, Bristol Myers Squibb&nbsp;&amp; Co&#8217;s (NYSE:<a class="ticker" href="https://www.benzinga.com/stock/BMY#NYSE">BMY</a>) Cobenfy (xanomeline and trospium chloride, KarXT) is poised to have less commercial competition.
The analyst also adds that the update will likely raise questions about strategy in neuroscience for AbbVie, which was highlighted during their <a target="_blank" href="https://www.benzinga.com/general/biotech/24/10/41626490/abbvie-tops-q3-expectations-as-skyrizi-rinvoq-drive-growth" rel="noreferrer noopener">third-quarter earnings call</a>.
The analyst, with a Buy rating and $215 price target, is still positive on AbbVie&#8217;s growth prospects particularly from their immunology I&amp;I franchise.
Emraclidine was part of AbbVie&#8217;s acquisition of Cerevel last year, which also included Tavapadon, which recently reported positive Phase 3 results in Parkinson&#8217;s disease.
The trial met its primary endpoint – patients treated with tavapadon in both dose groups experienced a statistically significant reduction (improvement) from baseline compared to placebo (placebo: +1.8; 5 mg: -9.7; 15 mg: -10.2 versus placebo) in the Movement Disorder Society – Unified Parkinson&#8217;s Disease Rating Scale (MDS-UPDRS) Parts II and III <a href="https://www.benzinga.com/general/biotech/24/09/41050209/abbvie-says-pivotal-trial-for-parkinsons-candidate-meets-its-primary-goal-in-patients-with-early-" target="_blank" rel="noreferrer noopener">combined score at week 26</a>.
Also Read: <a href="https://www.benzinga.com//node/41884798">AbbVie&#8217;s Emraclidine For Schizophrenia &#8216;Surprisingly Disappoints,&#8217; Analyst Says Pipeline Is Underappreciated</a>
BMO Capital Markets writes, &#8220;AbbVie core I&amp;I thesis intact, but this one stings.&#8221;
The analyst has lowered the <a target="_blank" href="https://www.benzinga.com/quote/ABBV/analyst-ratings" rel="noreferrer noopener">price target from $228</a> to $208 and maintains the Outperform rating, citing confidence in the immunology portfolio.
BMO analyst writes that While Neurocrine Biosciences Inc&#8217;s (NASDAQ:<a class="ticker" href="https://www.benzinga.com/stock/NBIX#NASDAQ">NBIX</a>) mixed phase 2 data from NBI-1117568 <a target="_blank" href="https://www.benzinga.com/analyst-ratings/analyst-color/24/08/40632561/neurocrine-biosciences-lower-dose-data-puts-its-schizophrenia-candidate-in-the-game" rel="noreferrer noopener">showed some efficacy</a>, there was absolutely no benefit in these trials. Bristol&#8217;s Cobenfy is now poised to dominate the schizophrenia market, the analyst adds.
BMO has reduced the probability of success for emraclidine to 0%, which was previously estimated to reach a potential $3.9 billion in global unadjusted peak sales in the Schizophrenia indication.
Price Action: ABBV stock is down 0.84% at $172.96 at last check Tuesday.
Photo via Shutterstock
Read Next:
<ul>
<li><a href="https://www.benzinga.com//node/41913107">Bristol-Myers Squibb&#8217;s $14 Billion Potential &#8211; Analyst Upgrades Stock</a></li>
</ul>

ABBV

AbbVie's Schizophrenia Failure Disappoints But Analysts Show Confidence In Immunology Portfolio

Solid Biosciences: Differentiating Factors Of SGT-212 To Set Itself Apart

Crinetics upgraded to buy by Jefferies, atumelnant potential cited

In a report released on January 21, Brian Abrahams from RBC Capital maintained a Hold rating on Neurocrine (NBIX – Research Report), with a price t...

RBC Capital Keeps Their Hold Rating on Neurocrine (NBIX)

Wells Fargo analyst Mohit Bansal has maintained their bullish stance on NBIX stock, giving a Buy rating on January 23. Mohit Bansal has given his B...

Promising Growth Trajectory and Positive Outlook for Neurocrine: Buy Rating Justified

Neurocrine Biosciences (NBIX) announced it has amended its agreement with Takeda (TAK) to develop and commercialize osavampator. Under the amended ...

Neurocrine announces amendment to collaboration with Takeda

An announcement from Neurocrine ( ($NBIX) ) is now available. On January 24, 2025, Neurocrine Biosciences announced an amendment to its Exclusive L...

Neurocrine Amends License Agreement with Takeda

Check out this evening's top movers from around Wall Street, compiled by The Fly.&nbsp;&nbsp; HIGHER AFTER EARNINGS – Sanmina (SANM) up 3.8% Brown ...

Closing Bell Movers: Graco down 5% as earnings, guidance miss

Neurocrine (NBIX) initiated a Phase 3 registrational study to evaluate the efficacy, safety and tolerability of osavampator, an investigational dru...

Neurocrine initiates Phase 3 registrational program for osavampator in MDD

Mizuho Securities analyst Uy Ear has maintained their neutral stance on NBIX stock, giving a Hold rating on January 21. Uy Ear has given his Hold r...

Cautious Outlook on Neurocrine Due to Developmental and Financial Uncertainties

UBS raised the firm's price target on Neurocrine (NBIX) to $176 from $162 and keeps a Buy rating on the shares. The firm expects Neurocrine to indi...

Neurocrine price target raised to $176 from $162 at UBS

ALPMF

ALPMY

BIIB

DSGN

LRMR

LXEO

PTCT

SANM

SLDB

TKPHF

TRNS

VYGR

Press Releases

Neurocrine Biosciences to Participate at Investor Conferences in December

Neurocrine Biosciences Announces FDA Approval of CRENESSITY™ (crinecerfont), a First-in-Class Treatment for Children and Adults With Classic Congenital Adrenal Hyperplasia

Neurocrine Biosciences Announces Commercial Availability of CRENESSITY™ (crinecerfont) for Children and Adults With Classic Congenital Adrenal Hyperplasia

Neurocrine Biosciences to Present at the 43rd Annual J.P. Morgan Healthcare Conference

Neurocrine Biosciences Announces Publication on Traditional Glucocorticoid Treatment in Classic Congenital Adrenal Hyperplasia in Expert Review of Endocrinology & Metabolism

Neurocrine Biosciences Announces Classic Congenital Adrenal Hyperplasia Supplement Published Today in The Journal of Clinical Endocrinology & Metabolism

Andrew Ratz, Ph.D., Joins Neurocrine Biosciences as Senior Vice President of Drug Development, Delivery and Device

Neurocrine Biosciences Announces Amendment to Strategic Collaboration with Takeda to Develop and Commercialize Osavampator (formerly NBI-1065845/TAK-653)

Neurocrine Biosciences Announces Initiation of Phase 3 Registrational Program for Osavampator as an Adjunctive Therapy for the Treatment of Major Depressive Disorder in Adults

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